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KMID : 0616120170480010025
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 1 p.25 ~ p.30
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Longevity Property of Ethyl acetate Fraction of Dried Zingiber officinale in Caenorhabditis elegans
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Lee Eun-Byeol
Kim Jun-Hyeong
Leem Jae-Yoon
Kim Hye-Soo
Kim Dae-Sung
Kim Ju-Eun
Kim Hyo-Shin
Lee Jeong-Ho
Moon Kwang-Hyun
Jeong Kyung-Ok
Han Soon-Cheon
Kim Dae-Keun
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Abstract
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This study was performed to evaluate the lifespan extending effects of the dried ginger (Zingiber officnale Roscoe, Zingiberaceae). Ethanol extract of the dried ginger was successively partitioned as methylene chloride, ethyl acetate, n-butanol and H2O soluble fractions, and lifespan-extending effects of the fractions were investigated using Caenorhabditis elegans model system. Ethyl acetate-soluble fraction showed the most potent longevity property. Furthermore, ethyl acetate-soluble fraction elevated thermal stress tolerance, and increased expression of stress resistance protein. Further studies were performed to investigate several aging-related factors such as reproduction, food intake, growth and movement of C. elegans. The results revealed that there were no significant changes in aging-related factors including reproduction, food intake and growth, however, ethyl acetate-soluble fraction treatment led to an up-regulation of locomotory ability of aged worms, suggesting ethyl acetate-soluble fraction affected healthspan as well as lifespan of nematode.
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KEYWORD
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Zingiber officinale, Caenorhabditis elegans, Longevity
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